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Endocrine Abstracts

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ea0034p242 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Evolutionary conserved novel targets of NGN3, located on the short arm of chromosome 20, may have a role in the development of the endocrine pancreas

Orekoya Oluwafikunayo , Berry Andrew , Hanley Neil

Background/aims: The transcription factor neurogenin 3 (NGN3) is required for pancreatic islet cell specification from multipotent progenitor cells; yet we have limited understanding of the downstream genetic program it directly initiates. A 3 Mb centromeric region on chromosome 20p contains a number of genes activated downstream of NGN3 including INSM1 and NKX2.2. We proposed that NGN3 alters the expression of other genes within this region as poten...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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